Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10058 |
A2B receptor antagonist 1
|
Adenosine Receptor | GPCR/G Protein; Neuroscience |
A2B receptor antagonist 1 是一个有效的 A2B 腺苷受体 (A2B adenosine receptor) 拮抗剂。 | |||
T26781 |
BF-1
BF1 |
||
BF-1 is a 5-Hydroxytryptamine receptor 2B antagonist. BF-1 was tested as potential migraine prophylactic drug by blocking BW723C86 (5-((thiophen-2-yl)methoxy)-α-methyltryptamine) or meta-chlorophenylpiperazine (mCPP) induced neurogenic dural plasma protei | |||
T60580 | A1AR antagonist 2 | ||
A1AR antagonist 2 (compound 18h) 是 A1腺苷受体 (A1 adenosine receptor) 的有效的选择性拮抗剂。A1AR antagonist 2对于 hA1, hA2A,hA2B 的Ki 值分别为 1.49、10.2 和 50.1 nM。 | |||
T38336 |
W140 (trifluoroacetate salt)
W140 (trifluoroacetate salt) |
||
Sphingosine-1-phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It exerts its activity by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. W140 is an inactive enantiomer of W146, a selective S1P1 antagonist (Ki = 77 nM), that binds to the S1P1 receptor with a Ki of 4.6 μM (2a = W146; 2b = W... | |||
T21558 |
MK-3207
|
||
MK-3207是口服生物相容性的CGRP 受体拮抗剂,IC50和 Ki 分别为 0.12 nM 和 0.024 nM,对 AM1,AM2,CTR 和 AMY3 的抑制性较弱。MK-3207可用于偏头痛研究。 |